POM Wonderful

Published studies are on POM Wonderful 100% Pomegranate Juice and POMx Polyphenol Extract. Patients received a minimum of 8 ounces of POM Wonderful 100% Pomegranate Juice or 850mg total pomegranate polyphenols per day.

Cardiovascular

Atherosclerosis:

• A randomized, placebo-controlled, double-blind clinical trial followed 289 subjects at moderate risk for coronary heart disease. These subjects consumed 8 ounces per day of either POM Wonderful 100% Pomegranate Juice or a placebo beverage. After 18 months, there was no reduction in the progression of intima-media thickness of the carotid artery (CIMT) in the POM group as a whole. However, further analysis revealed that the rate of CIMT progression slowed in nearly one third of POM patients, those with elevated cardiovascular disease risk factors. Read the Study.

• In a pilot study of 19 subjects with carotid artery stenosis (plaque buildup), patients who consumed 8 ounces of POM Wonderful 100% Pomegranate Juice daily for a one-year period experienced a 30% reduction in intima-media thickness of the carotid artery vs. a 9% increase for the placebo group. Read the study.

• In 13 healthy male volunteers who drank POM Wonderful 100% Pomegranate Juice for 2 weeks, the amount of LDL cholesterol oxidation decreased by 20% and antioxidant activity in the blood increased by 9%. Read the study.

Blood Flow / Pressure:

• In 45 subjects with ischemic coronary heart disease (reduced blood supply to the heart), coronary blood flow increased by 17% in the group consuming 8 ounces of pomegranate juice over a three-month period vs. 18% decrease in placebo group. Read the study.

• In a pilot study of 10 subjects with hypertension, reduction in ACE (angiotensin converting enzyme) activity and a slight decrease in systolic blood pressure was experienced after consuming POM Wonderful 100% Pomegranate Juice daily for two weeks. Read the study.

Prostate Cancer

• In a clinical study involving 46 men with rising PSA after prostate cancer treatment (surgery or radiation) who consumed 8 ounces of POM Wonderful 100% Pomegranate Juice daily over two years, PSA doubling time increased from 15 to 54 months (p <0.001).5 A longer term (6-year) continued evaluation of active sub-group patients showed a further increase in PSA doubling time to 88 months. Read the study.
* PSA doubling time is an indicator of prostate cancer progression.

Diabetes – Type II

• A pilot study followed 10 subjects with non-insulin dependent diabetes mellitus who consumed POM Wonderful 100% Pomegranate Juice daily over a 3-month period. These patients showed no negative effects on diabetic parameters. Additionally, a significant reduction in serum TBARS and lipid peroxidase (biomarkers of oxidative stress) were observed. Read the study.

• In a clinical study of 30 subjects with type II diabetes mellitus, patients consumed either POM Wonderful 100% Pomegranate Juice for four weeks, or POMx pomegranate polyphenol extract for 6 weeks. These patients showed no negative effects on diabetic parameters, and also experienced stabilization of the PON 1 enzyme and reduced serum oxidative stress. Read the study.

Erectile Function

• A randomized, placebo-controlled crossover pilot study of 55 men with mild to moderate erectile dysfunction evaluated the efficacy of consuming POM Wonderful variety pomegranate juice versus placebo. After consuming POM daily for 4 weeks, the men reported 50% greater likelihood of experiencing improved erections as compared to placebo. Read the study.

Drug Interactions / Safety

• In a study of 15 healthy volunteers, 8 ounces of pomegranate juice did not inhibit the activity of CYP-3A, a critical enzyme involved in metabolizing drugs. Read the study.

• After daily consumption of 8 ounces of pomegranate juice for one week, postmenopausal women did not experience increased serum estradiol or FSH levels. Read the study.

• In a clinical study with 86 increased-waist-size individuals who consumed POMx daily, no serious adverse events were experienced. Read the study.

Bioavailability

• A clinical bioavailability study showed direct evidence of the absorption of ellagic acid from pomegranate juice in humans, with maximum concentration achieved in the plasma one hour after consumption and rapid elimination by four hours. Read the study.

• A study of the pharmacokinetics of pomegranate juice in 18 healthy subjects demonstrated that the presence of ellagitannin metabolites in plasma and urine occurs in two phases: (a) within 6 hours post intake and (b) 12–48 hours following metabolism by colon microflora. Read the study.

• A study of 16 subjects showed that the absorption of active pomegranate ellagitannin metabolites, such as ellagic acid and urolithins, is similar whether delivered by POM Wonderful 100% Pomegranate Juice or POMx. Read the study.

Glycemic Index

• POM Wonderful 100% Pomegranate Juice has been tested by the international Glycemic Index (GI) Program and has been identified as a low-Glycemic Index food (GI=53).16 Read the study.

Antioxidant Potency

• POM Wonderful 100% Pomegranate Juice has been shown to have the highest Antioxidant Potency Index among several healthy beverages (red wine, Concord grape, blueberry, acai or cranberry juices) as measured by a composite of the four leading antioxidant capacity assays. Read the study.

Composition

• A study found that only 6 of 19 pomegranate supplements tested had compositions resembling that of pomegranates.  Most (13) had little or no detectable pomegranate-derived components.  POMx was the most similar to natural pomegranates and had the highest antioxidant capacity.  Read the study.

• A study of 27 pomegranate supplements found that only 5 had a typical pomegranate profile.  A total of 17 supplements contained little or no pomegranate and the remaining 5 had no detectable pomegranate.  The authors hypothesize that most of the supplements evaluated in this study may be less active than that of an authentic pomegranate supplement. Read the study.

Review Articles

• Literature Review: Overview of pomegranate juice polyphenols and inhibition of LDL cholesterol oxidation and cardiovascular disease. Read the article.

• Scientific and Clinical Monograph: Third party review of POM Wonderful published prostate and cardiovascular research through 2007. Read the article.

• POM Wonderful Prostate Cancer Research: Overview of POM Wonderful prostate cancer research portfolio. Read the article.

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