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POM’s Published Studies

Effects of Consumption of Pomegranate Juice on Carotid Intima-Media Thickness in Men and Women at Moderate Risk for Coronary Heart Disease
American Journal of Cardiology, 2009,
by M.H. Davidson et al.,
Absence of Pomegranate Ellagitannins in the Majority of Commercial Pomegranate Extracts: Implications for Standardization and Quality Control
Journal of Agricultural and Food Chemistry, 2009
by Yanjun Zhang, David Wang, Ru-Po Lee, Susanne M. Henning, and David Heber
Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis
Nutrition, 2008
by T.M. Haqqi, et al.
Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin
Experimental Dermatology, 2009
by H. Mukhtar, et al.
Inhibition of UVB-mediated Oxidative Stress and Markers of Photoaging in Immortalized HaCaT Keratinocytes by Pomegranate Polyphenol Extract POMx
Photochemistry and Photobiology, 2007
by H. Mukhtar, et al.
Pomegranate’s Ancient Roots to Modern Medicine, Pomegranates: Ancient Roots to Modern Medicine
Taylor and Francis, 2006
by M.P. Warren, et al.
Safety and Antioxidant Activity of a Pomegranate Ellagitannin-Enriched Polyphenol Dietary Supplement in Overweight Individuals with Increased Waist Size
Journal of Agricultural and Food Chemistry, 2007
by D. Heber, et al.
Pomegranate Juice Does Not Impair Clearance of Oral or Intravenous Midazolam, a Probe for Cytochrome P450-3A Activity: Comparison With Grapefruit Juice
Journal of Clinical Pharmacology, 2007
by D.J. Greenblatt, et al.
Pomegranates and Prostate Health: A Research Report
PCRI Insights, 2008
by M. Dreher, et al.
Scientific and Clinical Monograph for POM Wonderful Pomegranate Juice
American Botanical Council, 2008
by A. McCutcheon, Udani, and Brown, et al.
Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: Studies in atherosclerotic mice and in humans
Drugs Under Experimental and Clinical Research XXVIII, 2003
by M. Aviram, et al.
Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-κB in human KU812 cells
Journal of Inflammation, 2009
by T.M. Haqqi, et al.
Antioxidant, Antimalarial and Antimicrobial Activities of Tannin-Rich Fractions, Ellagitannins and Phenolic Acids from Punica granatum L.
Planta Medica, 2007
by D. Ferreira, et al.
Pomegranate seed oil consumption during a period of high-fat feeding reduces weight gain and reduces type 2 diabetes risk in CD-1 mice
British Journal of Nutrition, 2008
by B.K. McFarlin, et al.
Pomegranate juice sugar fraction reduces macrophage oxidative state, whereas white grape juice sugar fraction increases it
Atherosclerosis, 2006
by M. Aviram, et al.
Consumption of Wonderful Variety Pomegranate Juice and Extract by Diabetic Patients Increases Paraoxonase 1 Association with High-Density Lipoprotein and Stimulates Its Catalytic Activities
Journal of Agricultural and Food Chemistry, 2008
by M. Aviram, et al.
Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages
Atherosclerosis, 2006
by M. Aviram, et al.
International Multidimensional Authenticity Specification (IMAS) Algorithm for Detection of Commercial Pomegranate Juice Adulteration
Journal of Agricultural and Food Chemistry, 2009
by D. Heber, et al.
Pomegranate (Punica granatum) supplements: authenticity, antioxidant and polyphenol composition
Journal of Functional Foods, 2009
by Reed, et al.
Development of a novel pomegranate standard and new method for the quantitative measurement of pomegranate polyphenols
Journal of Science of Food and Agriculture, 2009
by Reed, et al.
Maternal Dietary Supplementation with Pomegranate Juice Is Neuroprotective in an Animal Model of Neonatal Hypoxic-Ischemic Brain Injury
Pediatric Research, 2005
by D.M. Holtzman, et al.
Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer’s disease
Neurobiology of Disease, 2006
by D.M. Holtzman, et al.
Effects of Pomegranate Juice and Extract Polyphenols on Platelet Function
Journal of Medicinal Food, 2009
by F.M. Pulcinelli, et al.
Oxidative Stress in Arteriogenic Erectile Dysfunction: Prophylactic Role of Antioxidants
Journal of Urology, 2005
by K.M. Azadzoi, et al.
Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study
International Journal of Impotence Research, 2007
by H. Padma-Nathan, et al.
Effects of Pomegranate Juice Consumption on Myocardial Perfusion in Patients With Coronary Heart Disease
American Journal of Cardiology, 2005
by D. Ornish, et al.
Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure
Atherosclerosis, 2001
by M. Aviram, et al.
Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR and AP-1 pathway activation
Atherosclerosis, 2007
by M. Aviram, et al.
Pomegranate Phenolics from the Peels, Arils, and Flowers Are Antiatherogenic: Studies in Vivo in Atherosclerotic Apolipoprotein E-Deficient (E0) Mice and in Vitro in Cultured Macrophages and Lipoproteins
Journal of Agricultural and Food Chemistry, 2008
by M. Aviram, et al.
Effects of a Pomegranate Fruit Extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis
Cardiovascular Research, 2007
by C. Napoli, et al.
Pomegranate juice reduces oxidized low-density lipoprotein downregulation of endothelial nitric oxide synthase in human coronary endothelial cells
Nitric oxide, 2006
by C. Napoli, et al.
Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide
Nitric oxide, 2006
by L.J. Ignarro, et al.
Beneficial effects of pomegranate juice on oxidation-sensitive genes and endothelial nitric oxide synthase activity at sites of perturbed shear stress
Proceedings of the National Academy of Sciences, 2005
by L.J. Ignarro et al.
Pomegranate Byproduct Administration to Apolipoprotein E-Deficient Mice Attenuates Atherosclerosis Development as a Result of Decreased Macrophage Oxidative Stress and Reduced Cellular Uptake of Oxidized Low-Density Lipoprotein
Journal of Agricultural and Food Chemistry, 2006
by M. Aviram, et al.
The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats
Nitric oxide, 2007
by C. Napoli, et al.
Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages
Journal of Nutritional Biochemistry, 2005
by M. Aviram, et al.
Pomegranate Juice Supplementation to Atherosclerotic Mice Reduces Macrophage Lipid Peroxidation, Cellular Cholesterol Accumulation and Development of Atherosclerosis
Journal of Nutrition, 2001
by M. Aviram, et al.
Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation
Clinical Nutrition, 2004
by M. Aviram, et al.
Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E–deficient mice
American Journal of Clinical Nutrition, 2000
by M. Aviram, et al.
Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo
International Journal of Oncology, 2008
by D. Heber, et al.
Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-KB-dependent mechanism
Molecular Cancer Therapy, 2008
by D. Heber, et al.
Pomegranate Ellagitannin-Derived Metabolites Inhibit Prostate Cancer Growth and Localize to the Mouse Prostate Gland
Journal of Agricultural and Food Chemistry, 2007
by D. Heber, et al.
Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor
Journal of Nutritional Biochemistry, 2008
by D. Heber, et al.
Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer
Clinical Cancer Research, 2006
by A. Pantuck, et al.
In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice
Journal of Nutritional Biochemistry, 2005
by D. Heber, et al.
Pomegranate Juice, Total Pomegranate Ellagitannins, and Punicalagin Suppress Inflammatory Cell Signaling in Colon Cancer Cells
Journal of Agricultural and Food Chemistry, 2006
by D. Heber, et al.
Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice
Clinica Chimica Acta, 2004
by D. Heber, et al.
Pomegranate Juice Ellagitannin Metabolites Are Present in Human Plasma and Some Persist in Urine for Up to 48 Hours
Journal of Nutrition, 2006
by D. Heber, et al.
Pomegranate Juice and Extracts Provide Similar Levels of Plasma and Urinary Ellagitannin Metabolites in Human Subjects
Journal of Medicinal Food, 2008
by D. Heber, et al.
Comparison of Antioxidant Potency of Commonly Consumed Polyphenol-Rich Beverages in the United States
Journal of Agricultural and Food Chemistry, 2008
by N. Seeram, et al.
Antioxidant Activity of Pomegranate Juice and Its Relationship with Phenolic Composition and Processing
Journal of Agricultural and Food Chemistry, 2000
by A.A. Kader, et al.